Gliotoxin can also induce the apoptosis of chronic lymphocytic leukemia cells (CLLs) (IC 50 between 0.1 and 1 M), associated with the inhibition of the NOTCH2/FCER2 (CD23) axis, together with the upregulation of the NOTCH3/NR4A1 axis and NF-B factor [87,88], thus providing a novel strategy for the treatment of CLLs
In early studies, the addition of oral L-carnitine or propionyl-L-carnitine to pharmacologic therapy for chronic stable angina modestly improved exercise tolerance and decreased electrocardiographic signs of ischemia during exercise testing in some angina patients (59-61)
Funk JL, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, Slyom AM, Timmermann BN
Need medical legitimacy and approved-label pathways